Pros
The overall mission of the institute is a good one. There are many very talented and dedicated people who truly want to change the world for the better, and it's rewarding to get to work with those people.
Cons
The founder of the institute left the role of President on January 1, 2012. Since then it's been a steady slide downhill. The new President seems incapable of leading and tends to make things more about himself than the science (and science is the reason for the institute's existence). There used to be excellent communication from the leadership to "the troops"; that has dried up. It doesn't feel that there is a direction to the institute at this point, and the "leadership" is not inspiring confidence in anyone other than themselves. Their core competency is apparently generating-corporate speak to explain why they aren't at fault for the economic issues the institute is having (all while spending as much as they want on themselves and on new upper-level staff).