Pros
Abundant and well-organized lab resources. Excellent engineering resources. Overall friendly and collaborative environment. Talented PR/advertising department will present your work and the Wyss Institute in a very positive light to the general public.
Cons
A lot of the research (especially in the bigger Wyss labs) boils down to repetitively testing drugs/therapeutics instead of making groundbreaking fundamental discoveries that have the potential to transform translational science. Even though many of the core faculty (PIs) are highly talented, the staff scientists tend to be more focused on managerial tasks than scientific innovation. Typically, research associates, PhD students, and postdocs do not aspire to be staff scientists at the Wyss Institute because they hope to land better/more respectable positions elsewhere.