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Interested in #immunemonitoring for #clinicalstudies? We have just the resource. Take a look at this curated selection of webinars: https://lnkd.in/giufX5m. Learn the basics of immune monitoring using #masscytometry and how it is used to quantify the frequencies, states and interactions of various immune cell subsets in the context of disease progression. #systemsbiology #immunology (Image from the #webinar, Maximizing Human Immune Monitoring with Mass Cytometry)
New streamlined #CyTOF workflow for whole blood defines a circulating immune cell signature of #COVID19 from Icahn School of Medicine at Mount Sinai. The team optimized a standardized, streamlined sample processing workflow to allow whole blood to be easily stained, stabilized, preserved and transferred to a central #masscytometry core for final processing and data acquisition The workflow leverages the Maxpar® Direct™ Immune Profiling Assay™ containing a 30‐ marker immunophenotyping panel in a single-tube dried-down format. “Pre-mixed dry antibody panels offer significant advantages over a conventional liquid antibody for #flowcytometry workflows by significantly reducing the processing time, technical variation and potential errors associated with pipetting multiple individual #antibodies, and these advantages are amplified when using larger antibody panels.”
New strains of the novel #coronavirus continue to emerge around the globe, triggering questions on whether current tests can detect these mutations. Join Mark Lynch in a discussion about critical needs for rapid, high-throughput genetic and epigenetic testing for SARS-CoV-2 and how an accurate, efficient, noninvasive saliva assay can meet these demands. Mark your calendars!
A scientist’s new year’s resolution #7: remain authentic and excel at being unique. We at Fluidigm pride ourselves on the uniqueness of our technology, innovating solutions to help our customers find success in their research and empower them to make a difference in our health, and our culture, supporting each other and working as a cohesive team in creative ways that brings out the best in all. Join us! https://lnkd.in/g2yzDWy
A group at Washington University School of Medicine in St. Louis discovered that #glioblastoma #stemcell subpopulations differ in signaling, self-renewal potential, and in vivo tumorigenicity. Knowledge of marker expression among these populations could help better understand tumor heterogeneity and treatment resistance. #Masscytometry was used to evaluate the intracellular states associated with four common GSC surface markers - measuring proliferation, migration, and tumorigenesis, core developmental pathways, their downstream effectors, and cancer-associated markers and finding 15 distinct GSC subpopulations in patients that correlated with outcome. “Mass cytometry… largely overcomes the spectral overlap typical of standard flow cytometry, which limits the number of observations possible on a given cell,” the paper states. https://lnkd.in/g6V-qZw
Join Fluidigm’s Steve Kulisch as he leads a discussion on Forging New Connections for a Sustainable Testing Ecosystem at this year’s PMWC LLC - Precision Medicine World Conference, focusing on #COVID19. The upcoming #PMWC21 conference is free and open to all and will present critical developments in #SARSCoV2 understanding, effects on healthcare systems and health data, and vaccine and therapeutics development based on effective clinical trials: https://lnkd.in/gaSAWrA #clinicaltrials #vaccines #healthcare #covidtesting #salivatest
Check out this video where Matt Cochran, Technical Director of the University of Rochester Medical Center Flow Cytometry Shared Resource Laboratory, shares some of the surprising findings from a pilot project that directly compared three flow panels to a single large #masscytometry panel. Find out what they uncovered by watching the video clip: https://lnkd.in/g6Dabdq #CyTOF #flowcytometry #cellrecovery #dataquality #workflows
Diagnosis of a pulmonary embolism can be challenging due to a variable and often non-specific clinical presentation. It is a complex multi-factorial disease caused by external and multiple genetic factors, but studies tend to focus on risk factors associated with venous thromboembolism. We would like to highlight this interesting work using #microfluidics. A team at Hannover Medical School conducted a large case-control genetic association study that evaluated the association of SNPs that are robustly associated with venous thromboembolism or deep vein thrombosis in previous studies in subjects who died from pulmonary embolism. The study provided supportive evidence for genetic differences at eight candidate risk loci between pulmonary embolism cases and controls: https://lnkd.in/gEKkMY2 #Biomark #realtimePCR #fluidicciruit #SNP #genetics #lunghealth #pulmonaryresearch
Join us for a live discussion on Wednesday, 20 January 2021! The SingHealth Translational Immunology Institute applies CyTOF® to characterize cellular diversity of the human immune system in the context of healthy human development and immune mediated diseases, such as cancer and autoimmune disorders. Using a growing collection of #CyTOF data from blood of clinically and demographically diverse human subjects, their team is building an immune atlas called EPIC (Extended Poly-dimensional Immunome Characterization), published in Nature: https://lnkd.in/guuunpd Hear about the project and how the group chose to intuitively analyze these complex multi-dimensional data: https://lnkd.in/g7GY42Q #immunology #celldiversity #cancer #autoimmune #translationalresearch
In a short period of time, #SARSCoV2 has impacted our lives, society and health care infrastructure. To address critical needs for clinical research and public health surveillance, we are working to support global laboratory efforts by delivering: Cost-efficient workflows that minimize reagent consumption using microfluidics technology Scalable throughput that enables the testing of thousands of samples per day Flexible panel designs that enable users to easily add, remove or change assays without changing technologies We continue to help labs implement high-throughput lab developed tests for SARS-CoV-2 research #clinicalresearch #publichealth #microfluidics #highthroughput #covidtesting
